The MMR system repairs incorrect insertions or deletions in the repetitive units of DNA known as microsatellites. A deficient MMR system contains gene mutations or gene expression that prevent it from functioning properly. Tumors with dMMR are more likely to respond to anti–PD-1 therapy due to increased mutations that promote anti-tumor immune cell reaction and increased tumor-infiltrating lymphocytes.11-13
Determine dMMR status using immunohistochemistry (IHC)
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